College Football Week 7 Odds and Preview: Ohio State at Indiana Leads the Slate
This week's odds: College football Week 11 odds, line moves and injuries.
Texas lost its unbeaten record to Oklahoma, Oregon lost at home to UCLA, and Kentucky beat LSU in overtime, and the college football Week 7 odds for Saturday, October 17, 2026, have moved hard since they opened.
Ohio State is a 2.5- to 3.5-point favorite at Indiana as of Friday night, October 16, 2026, LSU has gone from 10.5 at the open to 16.5 to 17.5 with Mississippi State's quarterback doubtful, Alabama is 7.5 at Tennessee after opening 7, and Oregon is 6.5 to 7.5 over Nebraska with its own quarterback change coming.
Week 6 in one paragraph
Saturday, October 10 reshaped the top of the sport. Oklahoma beat No. 1 Texas 27-24 with a late field goal, Georgia beat Alabama 20-17, UCLA won 17-15 at Oregon by stopping a late two-point try, and Kentucky beat LSU 35-34 in overtime.
Indiana rallied to win 20-17 at Nebraska, Ohio State beat Maryland 45-16, Notre Dame beat Stanford 58-7, and South Carolina won 38-19 at Florida. Scores verified on CBS Sports and Yahoo Sports.
College football Week 7 odds for every big game
| Kickoff | Game | Spread | Total | Moneyline (FanDuel) |
|---|---|---|---|---|
| 12:00 PM | Ohio State at Indiana | Ohio State -2.5 to -3.5 | 50.5 | -160 / +132 |
| 12:00 PM | Florida at Texas | Texas -10.5 to -11.5 | 51 to 51.5 | +320 / -420 |
| 12:00 PM | Mississippi State at LSU | LSU -16.5 to -17.5 | 55.5 to 57 | +580 / -880 |
| 3:30 PM | Alabama at Tennessee | Alabama -7.5 | 50.5 to 51 | -315 / +250 |
| 3:30 PM | Missouri at Ole Miss | Ole Miss -5.5 | 58.5 | +184 / -225 |
| 3:30 PM | Auburn at Georgia | Georgia -19.5 | 49.5 | +860 / -1600 |
| 3:30 PM | Arizona State at Texas Tech | Texas Tech -15.5 | 49.5 to 50.5 | +520 / -750 |
| 7:00 PM | Florida State at Miami (FL) | Miami -20.5 | 56 to 56.5 | +920 / -1800 |
| 7:30 PM | Notre Dame at BYU | Notre Dame -10.5 to -11.5 | 46 to 47 | -450 / +340 |
| 7:30 PM | Oklahoma State at Houston | Houston -4.5 | 62.5 | +160 / -194 |
| 7:30 PM | Wisconsin at UCLA | UCLA -2.5 | 42 to 43.5 | +114 / -137 |
| 10:15 PM | Utah at Colorado | Utah -14.5 to -15.5 | 49 to 49.5 | -780 / +530 |
| 11:00 PM | Nebraska at Oregon | Oregon -6.5 to -7.5 | 51.5 | +190 / -235 |
Spreads and totals are the range across BetMGM, bet365, DraftKings, FanDuel, Fanatics, BetRivers and Caesars on SportsbookReview's odds board, cross-checked against ScoresAndOdds. Moneylines are away / home at FanDuel.
Biggest college football line moves for Week 7
| Game | Opened | Now |
|---|---|---|
| Alabama at Tennessee | Alabama -7 | Alabama -7.5 |
| Wisconsin at UCLA | UCLA -3 | UCLA -2.5 |
| Mississippi State at LSU | LSU -10.5 | LSU -16.5 to -17.5 |
| Notre Dame at BYU | Notre Dame -11 | Notre Dame -10.5 to -11.5 |
| Ohio State at Indiana | Ohio State -4 | Ohio State -2.5 to -3.5 |
| Nebraska at Oregon | Oregon -6.5 | Oregon -6.5 to -7.5 |
"Opened" is the opening number on SportsbookReview's board, and "Now" is the board as of Friday night, October 16, 2026. Final injury reports Saturday morning can still move these numbers.
Quarterback news did most of the moving. LSU opened -10.5 and is 16.5 to 17.5 after Mississippi State's Kamario Taylor (turf toe) was downgraded to doubtful on Friday night. Alabama opened -7 and is 7.5, with George MacIntyre expected to start for Tennessee and Faizon Brandon off the report.
UCLA moved the other way, from 3 to 2.5, after CBS Sports reported quarterback Nico Iamaleava is expected to miss the rest of the season. Ohio State came off its -4 opener to 2.5 to 3.5, and Notre Dame is 10.5 at six books after opening 11.
Totals moved too: Alabama-Tennessee fell from 54.5 to 50.5 to 51, and Mississippi State-LSU dropped from 60.5 to 55.5 to 57. Our guide to line movement explains how news and money move numbers.
Ohio State vs Indiana odds
Both teams won close on Saturday in different ways: Ohio State pulled away from Maryland 45-16, while Indiana needed two fourth-quarter touchdowns to win 20-17 at Nebraska after trailing by 11. DraftKings opened Ohio State -4, and the books now straddle 3, with three at -2.5 and four at -3.5, while the total is 50.5 everywhere.
Receivers Brandon Inniss and Devin McCuin, who sat out against Maryland, are not on Thursday's Big Ten availability report, while running back Ja'Kobi Jackson and lineman Austin Siereveld are out.
Full breakdown, every book and the implied score: Ohio State vs Indiana prediction.
Alabama vs Tennessee odds
Alabama lost 20-17 at home to Georgia and the market still backs it: 7 at the open and 7.5 now at every book, while the total dropped from 54.5 to 50.5 to 51. Tennessee beat Arkansas 24-17 with George MacIntyre starting while Faizon Brandon (shoulder) was limited to emergency duty.
Brandon came off Friday's SEC availability report, but Volquest and other outlets report MacIntyre is expected to start again; Tennessee has not announced it. Alabama has ruled out receiver Ryan Coleman-Williams and center Racin Delgatty.
Full breakdown, every book and the implied score: Alabama vs Tennessee prediction.
Missouri vs Ole Miss odds
Ole Miss beat Vanderbilt 52-17 behind Trinidad Chambliss (213 passing yards, three touchdown passes and a rushing score), and Missouri beat Texas A&M 27-6 with Austin Simmons at quarterback. Ole Miss opened -6 and is 5.5 at every book, and the total has dropped from 59.5 at the open to 58.5.
Simmons is available after being listed probable, receiver Cayden Lee and left tackle Cayden Green moved to probable on Friday, and running back Ahmad Hardy is out.
Full breakdown, every book and the implied score: Missouri vs Ole Miss prediction.
Notre Dame vs BYU odds
BYU beat Iowa State 24-10, and Notre Dame is 10.5 at six books and 11.5 at FanDuel after opening 11, with the total down from 47.5 to 46.5. Kalani Sitake said there is no chance BYU running back LJ Martin plays, and Notre Dame cornerback Leonard Moore (concussion) is questionable but expected to play, per Marcus Freeman.
Full breakdown, every book and the implied score: Notre Dame vs BYU prediction.
Key college football injuries for Week 7
Statuses as of Friday night, October 16, 2026, from the week's availability reports and team comments. Final reports come out Saturday morning, so check again before kickoff.
| Player | Team | Pos | Status | Reported |
|---|---|---|---|---|
| Dante Moore | Oregon | QB | Out (concussion), second straight game. | Oct. 15 to 16 |
| Brock Thomas | Oregon | QB | Reported to start over Dylan Raiola (CBS Sports); Oregon has not announced it. | Oct. 16 |
| Kamario Taylor | Mississippi State | QB | Doubtful (turf toe), downgraded Friday; not expected to play, per ESPN. | Oct. 16 |
| Faizon Brandon | Tennessee | QB | Off Friday's report; George MacIntyre expected to start. | Oct. 16 |
| Aaron Philo | Florida | QB | Questionable (shoulder); Tramell Jones Jr. starts if he cannot. Decision Saturday. | Oct. 16 |
| Nico Iamaleava | UCLA | QB | Knee; expected to miss the season, per CBS Sports. Ty Dieffenbach is next. | Oct. 13 |
| Ryan Coleman-Williams | Alabama | WR | Out. | Oct. 16 |
| Racin Delgatty | Alabama | C | Out (lower leg). | Oct. 16 |
| Leonard Moore | Notre Dame | CB | Questionable (concussion); Marcus Freeman expects him to help. | Oct. 15 |
| LJ Martin | BYU | RB | Out; Kalani Sitake: no chance this week. | Oct. 14 |
| Whit Weeks | LSU | LB | Out (fractured fibula). | Oct. 16 |
| Ahmad Hardy | Missouri | RB | Out. | Oct. 16 |
Nebraska at Oregon is still the game most exposed to quarterback news. Dante Moore is out with a concussion, and CBS Sports reports Dan Lanning is expected to start Brock Thomas over Dylan Raiola, who was benched against UCLA; Oregon has not announced it. The line opened Oregon -6.5 and is 6.5 to 7.5.
Mississippi State at LSU moved the most on a quarterback: Kamario Taylor is doubtful, and LSU is 16.5 to 17.5 after opening 10.5. Florida's Aaron Philo (shoulder) is questionable, with a decision expected Saturday morning.
Other Week 7 games
Texas hosts Florida as a 10.5- to 11.5-point favorite after both lost on Saturday (our Florida vs Texas prediction has the full board). Georgia is a 19.5-point favorite over Auburn, and Miami is a 20.5-point favorite over Florida State, which lost 44-20 to Louisville.
Texas Tech is -15.5 against Arizona State, Houston is -4.5 against Oklahoma State with the highest total of the week (62.5), UCLA is only -2.5 against Wisconsin after losing Nico Iamaleava, and Utah is -14.5 to -15.5 at Colorado in the late window.
College football Week 7 betting questions
What is the spread for Ohio State vs Indiana?+
Who is favored in Alabama vs Tennessee?+
What is the line for Nebraska vs Oregon?+
What is the biggest spread in college football Week 7?+
When do college football injury reports come out?+
Next up: the college football Week 8 preview has the October 24 lines, including Ole Miss at Texas.
Last week's preview: college football Week 6 preview. New to spreads? Read what a point spread is or start at the betting basics hub.