Ohio State vs Indiana Prediction and Odds: Week 7 2026

No. 4 Ohio State at No. 5 Indiana is a rematch of last December's Big Ten title game, which Indiana won 13-10, and Indiana brings a 22-game winning streak into it. The books make Ohio State a road favorite of 2.5 to 3.5 points, as of Friday night, October 16, 2026, down from -4 at the open, with the total at 50.5 everywhere. Turn those numbers into a score and the betting market's Ohio State vs Indiana prediction is Ohio State 27, Indiana 23.5.

Ohio State vs Indiana odds at every book

Here is the board for Ohio State at Indiana on Saturday, October 17, 2026, at noon ET on FOX at Memorial Stadium in Bloomington, as of Friday night, October 16, 2026. DraftKings opened Ohio State -4, and the books now split around 3: BetMGM, DraftKings and Fanatics hang -2.5 at a steep price (-125 to -135), while bet365, FanDuel, BetRivers and Caesars deal -3.5 at about even money. Lines are from SportsbookReview's board, checked against ScoresAndOdds. Indiana +133 at Caesars is the best price on the Hoosiers, bet365 has the cheapest Ohio State moneyline at -154, and the total is 50.5 at every book. Compare where you have accounts on our sportsbooks page.

Ohio State vs Indiana prediction from the betting odds

The line now sits right on 3, the most common margin in football: Ohio State -2.5 wins with a 3-point victory, while Ohio State -3.5 needs 4 or more, which is why the -2.5 books charge -125 to -135 for it. That half point is worth shopping for, and our guide to key numbers explains why. The total opened at 50.5 and is 50.5 at all seven books now.

How Ohio State and Indiana got here

Ohio State's only loss is 24-23 at Texas on September 12, when the Longhorns came back from 20 down in the fourth quarter. Indiana is 6-0, but its last game was its closest: a 20-17 win at Nebraska in which the Hoosiers trailed 17-6 and ran for a season-low 65 yards.

Ohio State: Julian Sayin and Jeremiah Smith

Ohio State quarterback Julian Sayin threw for 242 yards and four touchdowns, with one interception returned for a score, in the 45-16 win over Maryland on October 10. Jeremiah Smith caught four passes for 93 yards and two touchdowns, and he leads our Heisman odds board. Ohio State's defense held Maryland to 146 total yards.

Indiana: Josh Hoover and a 22-game streak

Indiana quarterback Josh Hoover has thrown for 1,364 yards, 17 touchdowns and no interceptions through six games. At Nebraska he went 12 of 22 for 263 yards and two touchdowns, both to Nick Marsh, who caught six passes for 187 yards, including a 44-yard go-ahead score on fourth-and-1. The win stretched Indiana's streak to 22 games, the longest active run in the Big Ten, and Indiana is the defending national champion.

Ohio State and Indiana injury report

Ohio State's second Big Ten availability report, released Thursday night, October 15, lists running back Ja'Kobi Jackson, offensive linemen Austin Siereveld and Jaxon Powell, safeties Leroy Roker III and Khmari Bing and receiver Amari Valerio-Hudson as out, with receiver Brock Boyd and running back Anthony "Turbo" Rogers questionable. Receivers Brandon Inniss and Devin McCuin, linebacker Christian Alliegro, cornerback Jay Timmons and tackle Phillip Daniels, who all sat out the Maryland game, are not on the report, and Khary Wilder, Deontae Armstrong and Isaiah West were removed from it on Thursday. Indiana lists running back Khobie Martin as doubtful and tight end Andrew Barker as questionable, unchanged from Wednesday, and neither quarterback is on either report. Status as of Friday night, October 16; the final report comes Saturday morning.

Ohio State vs Indiana series history

Ohio State leads the all-time series by a wide margin: 82-13-5 by Ohio State's count, or 80-13-5 by Winsipedia's, which handles a vacated win differently.

Ohio State vs Indiana questions