Missouri vs Ole Miss Prediction and Odds: Week 7 2026

This week's odds: College football Week 11 odds and line moves and our College Football Playoff predictions.

No. 13 Missouri goes to No. 9 Ole Miss off a 27-6 win over Texas A&M, and the books make Ole Miss a 5.5-point favorite at all seven major books as of Friday night, October 16, 2026 (the opener was -6), with the total at 58.5 everywhere. Missouri quarterback Austin Simmons, listed probable earlier in the week, is available. Missouri has beaten Ole Miss six straight times, and both teams have a shared reference point: Florida, which beat Ole Miss 52-28 and then lost 45-17 at Missouri. The betting market's Missouri vs Ole Miss prediction is Ole Miss 32, Missouri 26.5.

Missouri vs Ole Miss odds at every book

Here is the board for Missouri at Ole Miss on Saturday, October 17, 2026, as of Friday night, October 16, 2026. All seven books have Ole Miss -5.5 and a 58.5 total. DraftKings has the longest Missouri moneyline at +185, and BetRivers has the steepest Ole Miss price at -240. The board was checked against ScoresAndOdds; see where you can bet on our sportsbooks page.

Missouri vs Ole Miss prediction from the betting odds

The spread has barely moved from the Ole Miss -6 opener and settled at -5.5 everywhere, and the total is a point lower than the 59.5 opener. Most books charge -110 to -118 on Missouri +5.5, so the half point is priced in. Ole Miss -5.5 means a 6-point Rebels win covers, while a 5-point win cashes Missouri +5.5.

How Missouri and Ole Miss got here

Missouri's only loss is 31-24 at Mississippi State on September 26, and it has won its last two by a combined 72-23. Ole Miss's only loss is 52-28 at Florida on September 26, and it came out of its bye with a 52-17 win at Vanderbilt.

Missouri: Jamal Roberts and back-to-back 200-yard games

Missouri running back Jamal Roberts carried 34 times for 222 yards and two touchdowns against Texas A&M, his second straight 200-yard game after 211 yards and three touchdowns against Florida.

Ole Miss: Trinidad Chambliss and a healthy Kewan Lacy

Ole Miss quarterback Trinidad Chambliss threw for 213 yards and three touchdowns and ran for another in the 52-17 win at Vanderbilt, where Ole Miss led 42-3 at halftime and scored 24 points off four turnovers. Running back Kewan Lacy returned in that game after missing the Florida loss, with seven carries for 39 yards and a touchdown.

Missouri and Ole Miss injury report

From the SEC availability reports on Wednesday, Thursday and Friday, October 14 to 16, confirmed by On3, Yahoo Sports and The Rebel Walk. Missouri quarterback Austin Simmons was listed probable on Thursday, his first designation of the season, and is available. Receiver Cayden Lee, the SEC's receiving yards leader, and left tackle Cayden Green moved to probable on Friday. Running back Ahmad Hardy is out again, along with right tackle Josh Atkins. For Ole Miss, safety Edwin Joseph is out and safety MJ Preston and tight end Hayden Bradley are questionable.

Missouri vs Ole Miss series history

Missouri leads the all-time series 7-1 and has won six straight meetings; Ole Miss's only win came in 1974. This is Missouri's first trip to Oxford since 2013.

Missouri vs Ole Miss questions