NFL Week 6 Odds and Predictions 2026: Lines, Moves, Injuries
This week's odds: NFL Week 10 odds, line moves and injuries.
NFL Week 6 opened Thursday night with the Denver Broncos beating the Seattle Seahawks 17-14 in overtime as 2.5-point underdogs.
For Sunday, the Los Angeles Rams are the biggest favorite on the board at 12.5 over Arizona as of Friday night, October 16, 2026, and Friday's injury reports settled three quarterback questions and left one open: Lamar Jackson (ankle) and Jalen Hurts (calf) are out, Michael Penix Jr. starts for Atlanta, and Caleb Williams (hamstring) is questionable.
Baltimore fell back to -3 to -3.5 at Cleveland, and Carolina is now a 3 to 3.5-point favorite at Philadelphia.
NFL Week 6 odds for every game
| Kickoff | Game | Spread | Total | DK ML |
|---|---|---|---|---|
| Thu (final) | Seahawks at Broncos | DEN won 17-14 (OT) | 31, under 40.5 | DEN +120 won |
| Sun 9:30 AM | Texans at Jaguars | JAX -2.5 | 42.5 | +124 / -148 |
| Sun 1:00 PM | Titans at Colts | IND -6.5 | 44.5 | +270 / -340 |
| Sun 1:00 PM | Panthers at Eagles | CAR -3 to -3.5 | 38.5 to 39.5 | -170 / +142 |
| Sun 1:00 PM | Steelers at Buccaneers | PIT -2.5 | 38.5 to 39.5 | -148 / +124 |
| Sun 1:00 PM | Ravens at Browns | BAL -3 to -3.5 | 39.5 | -166 / +140 |
| Sun 1:00 PM | Saints at Giants | NO -1.5 | 45.5 to 46.5 | -110 / -110 |
| Sun 1:00 PM | Bears at Falcons | CHI -1.5 | 51.5 to 52 | -118 / -102 |
| Sun 1:00 PM | Jets at Patriots | NE -7.5 | 43 to 43.5 | +275 / -345 |
| Sun 4:05 PM | Cardinals at Rams | LAR -12.5 | 51.5 | +550 / -800 |
| Sun 4:25 PM | Chargers at Chiefs | KC -7.5 | 41 to 41.5 | +340 / -440 |
| Sun 4:25 PM | Bills at Raiders | BUF -4.5 to -5.5 | 53 to 53.5 | -230 / +190 |
| Sun 8:20 PM | Cowboys at Packers | GB -1.5 | 52.5 to 53.5 | -105 / -115 |
| Mon 8:15 PM | Commanders at 49ers | SF -7.5 | 51.5 to 52.5 | +330 / -425 |
DraftKings still shows San Francisco -5.5 against a -425 moneyline on SportsbookReview's board, while every other book is at 7.5; we left it out of the range.
Lines move until kickoff, especially with a quarterback still in doubt in Chicago. Shop the number before you bet: half a point on Ravens -3 versus -3.5 or Panthers -3 versus -3.5 sits right on the most common NFL margin. Our guide to key numbers explains why, and you can compare books on our sportsbooks page.
Biggest NFL Week 6 line moves
| Game | Opened | Now |
|---|---|---|
| Panthers at Eagles | PHI -1.5, total 43.5 | CAR -3 to -3.5, total 38.5 to 39.5 |
| Saints at Giants | NYG -1.5 | NO -1.5 |
| Cowboys at Packers | DAL -1, total 50 | GB -1.5, total 52.5 to 53.5 |
| Chargers at Chiefs | KC -7.5, total 45.5 | KC -7.5, total 41 to 41.5 |
| Bears at Falcons | CHI -2, total 48 | CHI -1.5, total 51.5 to 52 |
| Texans at Jaguars | JAX -1.5, total 40.5 | JAX -2.5, total 42.5 |
| Ravens at Browns | BAL -3.5, total 40.5 | BAL -3 to -3.5, total 39.5 |
Three games have flipped favorites since the open. Panthers-Eagles moved the most: Philadelphia opened -1.5 and Carolina is now -3 to -3.5, with the total down about four and a half points, after the Eagles ruled out Jalen Hurts (calf) and Saquon Barkley (hamstring) and named Tanner McKee the starter.
New Orleans went from a 1.5-point underdog at the Giants to a 1.5-point favorite, and Green Bay from +1 to -1.5 against Dallas. The Chiefs-Chargers total is down four points from 45.5, and the Bears-Falcons total is up three and a half with Penix cleared to start.
Seahawks vs. Broncos: Thursday Night Football final
Both teams came in 3-2; Denver is now 4-2 and Seattle 3-3. Our Seahawks vs Broncos page has how every bet settled and the pregame board.
Ravens vs. Browns: Lamar Jackson is out
Baltimore is 4-1 and has won three straight, the latest a 30-23 overtime win at Atlanta in Tyler Huntley's first start of the season. Jesse Minter ruled Lamar Jackson out on Friday for the second straight week, and the line is back to the -3.5 opener at most books.
Cleveland lost 17-12 at the Jets and is 3-2; running back Quinshon Judkins (ankle) and linebacker Carson Schwesinger (ankle) are questionable, backup quarterback Dillon Gabriel (back) is out, and receiver KC Concepcion cleared the concussion protocol. Full board: Ravens vs Browns prediction.
Bears vs. Falcons: Caleb Williams is questionable
Chicago lost 31-7 at Green Bay with Tyson Bagent, who gave way to Case Keenum in the fourth quarter. The Bears opened -2 and are -1.5 at every book, while the total is up from 48 to 51.5 to 52 with Michael Penix Jr. (ribs) cleared to start for Atlanta.
Caleb Williams practiced fully all week but is listed as questionable, with a decision expected Saturday. The Bears are also without Montez Sweat, suspended, and linebackers T.J. Edwards and Keyshaun Elliott are out. Full board: Bears vs Falcons prediction.
Cowboys vs. Packers: Sunday Night Football
The Packers are 3-2 and hold the NFC No. 5 seed after the rout of Chicago, while Dallas is 2-3 after losing 24-16 at home to Tampa Bay. The line flipped from Cowboys -1 to Packers -1.5 at all seven books, and the total is 52.5 to 53.5, up from 50.
DraftKings makes it close to a coin flip, 51.1% to 48.9% for Green Bay with the vig removed. Micah Parsons is still on the PUP list and is not expected to play, and Javon Hargrave (Achilles) and Jonathan Ford (calf) are out.
CeeDee Lamb carries no designation. Full board: Cowboys vs Packers prediction.
NFL Week 6 key injuries and player status
| Player | Team | Pos | Status |
|---|---|---|---|
| Lamar Jackson | BAL | QB | Out (ankle); Tyler Huntley starts |
| Jalen Hurts | PHI | QB | Out (calf); Tanner McKee starts |
| Baker Mayfield | TB | QB | Out (thumb); Jalon Daniels starts |
| Caleb Williams | CHI | QB | Questionable (hamstring) |
| Michael Penix Jr. | ATL | QB | No designation, starts |
| Saquon Barkley | PHI | RB | Out (hamstring) |
| Quinshon Judkins | CLE | RB | Questionable (ankle) |
| Rashee Rice | KC | WR | Out (hamstring) |
| Breece Hall | NYJ | RB | Out (quad) |
| A.J. Brown | NE | WR | Questionable (ankle) |
| Will Campbell | NE | LT | Questionable (knee) |
| Alvin Kamara | NO | RB | Questionable (back) |
| Micah Parsons | GB | DE | PUP; not expected to play |
| Deebo Samuel | SF | WR | Did not practice Friday (hamstring) |
Statuses can change before kickoff. A.J. Brown needs to be activated from injured reserve by Saturday afternoon to play, Chicago decides on Williams Saturday, and Washington and San Francisco post final designations for Monday night on Saturday.
Other NFL Week 6 games
In London, the Jaguars (4-1) are 2.5-point favorites over Houston (1-4), and the total has climbed from 40.5 to 42.5. Houston added wide receiver Marvin Harrison Jr. in a trade with Arizona. The Colts are 6.5-point home favorites over winless Tennessee, and the Patriots lay 7.5 against the Jets (Jets vs Patriots prediction).
Kansas City is a 7.5-point favorite over the 0-5 Chargers without Rashee Rice, with the total down from 45.5 to 41 to 41.5. Buffalo, 4-1, is a 4.5 to 5.5-point favorite at Las Vegas with the highest total of the week.
Pittsburgh is a 2.5-point favorite at Tampa Bay, where Jalon Daniels starts for Baker Mayfield, and the week closes Monday with San Francisco laying 7.5 against Washington. Our Commanders vs 49ers prediction has that full board, and our Week 6 survivor picks rank every favorite by win probability.