Commanders vs 49ers Prediction and Odds: Monday Night Football Week 6
This week's odds: NFL Week 10 odds, line moves and injuries.
The unbeaten San Francisco 49ers are 7.5-point favorites over the Washington Commanders for Monday Night Football as of Friday night, October 16, 2026, and the total has climbed from 50.5 to 52 at most books. San Francisco is 5-0 after a 32-29 win at Seattle, and Washington is 1-3-1 after a 27-27 overtime tie with the New York Giants. Turn the numbers into a score and the betting market's Commanders vs 49ers prediction is San Francisco 29.75, Washington 22.25.
Commanders vs 49ers odds at every book
Here is the board for the Washington Commanders at the San Francisco 49ers on Monday, October 19, 2026, at 8:15 PM ET at Levi's Stadium on ESPN and ABC, as of Friday night, October 16, 2026. Six books are at San Francisco -7.5, and the total runs from 51.5 at FanDuel to 52.5 at bet365 and Fanatics. Washington's best moneyline is +330 at bet365, DraftKings and FanDuel. The board was checked against ScoresAndOdds. Compare books on our sportsbooks page.
| Book | Spread | Moneyline (WAS / SF) | Total |
|---|---|---|---|
| BetMGM | 49ers -7.5 (-108) | +310 / -400 | 52 |
| bet365 | 49ers -7.5 (-108) | +330 / -420 | 52.5 |
| DraftKings | 49ers -5.5* (-110) | +330 / -425 | 50.5* |
| FanDuel | 49ers -7.5 (-108) | +330 / -420 | 51.5 |
| Fanatics | 49ers -7.5 (-105) | +310 / -400 | 52.5 |
| BetRivers | 49ers -7.5 (-107) | +325 / -455 | 52 |
| Caesars | 49ers -7.5 (-109) | +320 / -420 | 52 |
*SportsbookReview's board still shows DraftKings at San Francisco -5.5 with a 50.5 total, which does not match DraftKings' -425 moneyline or ScoresAndOdds, where the spread is 7.5. We treat the DraftKings spread as stale. The spread has held at 7.5 all week, a half point above 7, the second most common NFL margin: a one-touchdown 49ers win covers for Washington +7.5. The total is the number that moved, up a point and a half from the 50.5 opener.
Commanders vs 49ers prediction from the betting odds
The market prices San Francisco as one of the best teams in the league and Washington as a team with a negative point differential. The 49ers have outscored opponents by 61 points; the Commanders have been outscored by 34.
How the Commanders and 49ers got here
San Francisco is 5-0 and leads the NFC West after beating Seattle 32-29 on a 44-yard Eddy Piñeiro field goal with two minutes left. Washington has used three quarterbacks: Jayden Daniels dislocated his left elbow in Week 2, Marcus Mariota won in Week 3 and then sprained his right MCL in London, and Daniels returned in Week 5. Washington led the Giants 27-13 in the fourth quarter and settled for a tie when time ran out in overtime with the ball at the Giants' 24.
| Week | Commanders | 49ers |
|---|---|---|
| 1 | L 22-24 at Eagles | W 27-7 vs Rams (Melbourne) |
| 2 | L 20-37 at Cowboys | W 35-13 vs Dolphins |
| 3 | W 33-31 vs Seahawks | W 36-30 vs Cardinals |
| 4 | L 13-30 vs Colts (London) | W 24-14 vs Broncos |
| 5 | T 27-27 (OT) vs Giants | W 32-29 at Seahawks |
San Francisco: Purdy and a thinning receiver room
Brock Purdy has completed 69% of his passes for 1,196 yards, 13 touchdowns and two interceptions in five starts. Mike Evans caught seven passes for 113 yards and a touchdown at Seattle while playing through a rib injury. Deebo Samuel strained his right hamstring in that game, and Kyle Shanahan said he will miss "some time." Linebacker Dre Greenlaw is suspended for this game after his appeal of a one-game ban for headbutting a Seattle player was denied.
Washington: Daniels back, Diggs in doubt
Jayden Daniels played all of the Giants game, going 17 of 25 for 199 yards and running nine times for 103 yards and two touchdowns. Since the start of 2025 he has played a full game only five times, per Field Level Media. Stefon Diggs (hamstring) missed Week 5, and Terry McLaurin returned from a hamstring injury with four catches for 62 yards.
Commanders vs 49ers injury report
For a Monday game, final game designations come out Saturday. This is the Friday, October 16 practice report, confirmed by 49ersWebzone, the Commanders' official report as posted by beat reporters, and Yahoo Sports. Jayden Daniels (left elbow) was a full participant. San Francisco held Nick Bosa (knee, calf), Mike Evans (ribs, Achilles) and Deebo Samuel (hamstring) out of practice, and Washington held Terry McLaurin (hamstring, rest) and running back Jacory Croskey-Merritt (groin) out, while Stefon Diggs (hamstring) was limited.
| Player | Team | Pos | Friday practice |
|---|---|---|---|
| Jayden Daniels | WAS | QB | Full (left elbow) |
| Terry McLaurin | WAS | WR | Did not practice (hamstring, rest) |
| Jacory Croskey-Merritt | WAS | RB | Did not practice (groin) |
| Marcus Mariota | WAS | QB | Did not practice (knee) |
| Stefon Diggs | WAS | WR | Limited (hamstring) |
| Austin Ekeler | WAS | RB | Limited (chest) |
| Nick Bosa | SF | DE | Did not practice (knee, calf) |
| Mike Evans | SF | WR | Did not practice (ribs, Achilles) |
| Deebo Samuel | SF | WR | Did not practice (hamstring) |
| Christian Kirk | SF | WR | Limited (calf) |
| Christian McCaffrey | SF | RB | Full (rest) |
| Trent Williams | SF | T | Full (rest) |
Commanders vs 49ers head-to-head
San Francisco has won the last two meetings, 27-10 at Washington on December 31, 2023, and 37-20 at Levi's Stadium in 2022.
| Date | Site | Result |
|---|---|---|
| Dec 31, 2023 | Washington | 49ers 27, Commanders 10 |
| Dec 24, 2022 | Santa Clara | 49ers 37, Commanders 20 |
| Dec 13, 2020 | Glendale, Ariz.* | Washington 23, 49ers 15 |
| Oct 20, 2019 | Washington | 49ers 9, Washington 0 |
| Oct 15, 2017 | Washington | Washington 26, 49ers 24 |
*A 49ers home game moved to State Farm Stadium because of Santa Clara County COVID restrictions.