NFL Week 10 Preview 2026: Odds, Line Moves and Injuries
NFL Week 10 opens Thursday night with the Washington Commanders at the New York Giants, and the Giants are 1.5 to 2.5-point favorites as of Tuesday, November 10, 2026, 9:10 AM ET. Sunday starts early: the New England Patriots and Detroit Lions play in Munich at 9:30 AM ET, with Detroit -2.5.
The biggest spread is the Jacksonville Jaguars -9.5 to -10.5 at Tennessee. The highest total is San Francisco at Dallas at 55.5 to 56.5. The Bears, Broncos, Eagles and Buccaneers are on bye, and the Bills closed Week 9 with a 23-6 win at Minnesota on Monday night.
NFL Week 10 odds for every game
| Kickoff (ET) | Game | Spread | Total | Moneyline, FanDuel (away / home) |
|---|---|---|---|---|
| Commanders at Giants | Thu 8:15 PM, Prime Video | Giants -1.5 to -2.5 | 41.5 to 42.5 | +108 / -126 |
| Patriots at Lions (Munich) | Sun 9:30 AM, FOX | Lions -2.5 | 51 to 51.5 | +130 / -154 |
| Panthers at Saints | Sun 1:00 PM, FOX | Saints -1.5 | 47.5 to 48.5 | -104 / -112 |
| Bills at Jets | Sun 1:00 PM | Bills -7.5 to -8.5 | 50.5 | -430 / +340 |
| Texans at Browns | Sun 1:00 PM, FOX | Texans -4.5 to -5 | 39.5 to 40 | -230 / +190 |
| Jaguars at Titans | Sun 1:00 PM, FOX | Jaguars -9.5 to -10.5 | 45.5 to 46.5 | -550 / +410 |
| Chiefs at Falcons | Sun 1:00 PM | Chiefs -3.5 | 45 to 45.5 | -172 / +144 |
| Dolphins at Colts | Sun 1:00 PM | Colts -1.5 to -2.5 | 40.5 | +114 / -134 |
| Vikings at Packers | Sun 1:00 PM, FOX | Packers -4.5 | 40.5 to 42.5 | +148 / -176 |
| Rams at Cardinals | Sun 4:05 PM | Rams -8.5 to -9.5 | 39.5 to 40.5 | -340 / +275 |
| Seahawks at Raiders | Sun 4:05 PM | Seahawks -3.5 | 43 to 43.5 | -180 / +152 |
| 49ers at Cowboys | Sun 4:25 PM, FOX | 49ers -3.5 to -4.5 | 55.5 to 56.5 | -215 / +180 |
| Steelers at Bengals | Sun 8:20 PM, NBC | Bengals -3.5 | 48.5 | +166 / -198 |
| Chargers at Ravens | Mon 8:15 PM, ESPN | Ravens -4.5 to -5.5 | 37.5 to 38.5 | +194 / -235 |
Spreads and totals are the range across six books on SportsbookReview: BetMGM, bet365, FanDuel, Fanatics, BetRivers and Caesars. We left the DraftKings column out because it has been stale on the NFL board this season. Moneylines are FanDuel. For 1H spreads and totals, see our NFL first half lines page.
We cross-checked every line against VegasInsider's Week 10 board, updated late Monday night, and every favorite matches, including New Orleans over Carolina. BetRivers showed a pick'em on Commanders at Giants with a big moneyline, so we treat it as not posted. Our free plays for the week go up on our free picks page.
Biggest NFL Week 10 line moves
| Game | Spread opened | Spread now | Total opened | Total now |
|---|---|---|---|---|
| Vikings at Packers | Packers -3 | Packers -4.5 | 42 | 40.5 to 42.5 |
| Panthers at Saints | Panthers -1.5 | Saints -1.5 | 47.5 | 47.5 to 48.5 |
| Rams at Cardinals | Rams -8.5 | Rams -8.5 to -9.5 | 47.5 | 39.5 to 40.5 |
| Chargers at Ravens | Ravens -2.5 | Ravens -4.5 to -5.5 | 38.5 | 37.5 to 38.5 |
| Texans at Browns | Texans -3.5 | Texans -4.5 to -5 | 38.5 | 39.5 to 40 |
| Patriots at Lions | Lions -1.5 | Lions -2.5 | 48.5 | 51 to 51.5 |
| Chiefs at Falcons | Chiefs -3 | Chiefs -3.5 | 47 | 45 to 45.5 |
| Dolphins at Colts | Colts -2.5 | Colts -1.5 to -2.5 | 42.5 | 40.5 |
| Bills at Jets | Bills -8.5 | Bills -7.5 to -8.5 | 49.5 | 50.5 |
| Jaguars at Titans | Jaguars -10 | Jaguars -9.5 to -10.5 | 45.5 | 45.5 to 46.5 |
| Steelers at Bengals | Bengals -4 | Bengals -3.5 | 48.5 | 48.5 |
The openers above are the Sunday-night numbers posted after Week 9's Sunday games. Baltimore opened 2.5 and is 4.5 to 5.5 against the 0-8 Chargers, and coach Jesse Minter now expects Jacoby Brissett to start.
The Rams-Cardinals total fell the furthest, from 47.5 to 39.5 to 40.5. Gardner Minshew hurt his elbow against Seattle and is feared to have a torn UCL, so rookie Carson Beck is in line to start. The Rams are 8.5 to 9.5 with Puka Nacua expected to go on injured reserve.
The Packers went from 3 to 4.5 after Carson Wentz went 8 of 25 for 81 yards in Minnesota's 23-6 loss to Buffalo. Carolina opened a 1.5-point favorite in New Orleans, and every book now has the Saints by 1.5. Texans at Browns moved from 3.5 to 4.5 to 5, with Deshaun Watson reported as Cleveland's starter.
Expert NFL picks context: three Week 10 games to watch
Thursday night: the Giants are 1.5 to 2.5-point favorites over the Commanders (FanDuel +108 / -126, total 41.5 to 42.5), an implied score of about 22 to 19.5.
The Giants (5-2-1) beat the Eagles 19-11 on Sunday and hold the NFC 3 seed. J.J. McCarthy hurt his hip in that game and was limited on Monday's estimated report, but John Harbaugh expects him to play. The Commanders (2-5-1) lost 20-13 to the Rams.
The Lions (6-2) beat the Dolphins 19-9, and the Patriots (5-4) lost 45-27 at home to the Packers. Detroit went from 1.5 to 2.5 and the total from 48.5 to 51 to 51.5. This is the only Week 10 game outside the United States.
The Vikings (6-2) lost 23-6 to Buffalo on Monday night, and Kyler Murray has a Grade 2 hamstring strain and is week to week. The Packers (6-3) scored 45 in New England. Josh Jacobs has a fractured finger.
The Steelers (6-2) come off a bye and lead the AFC North on tiebreakers. The Bengals (6-2) beat the Falcons 34-17 in Madrid. Prediction markets give Cincinnati a 63% chance to win the division and Pittsburgh 30%, so Sunday night swings that race.
Key NFL Week 10 injuries
| Player | Team | Status, as of Nov. 10 | Sources |
|---|---|---|---|
| Lamar Jackson, QB | Ravens | Right thumb, on IR. Coach Jesse Minter said he needs surgery that could end his season. | AP, Ravens.com |
| Jacoby Brissett, QB | Ravens | Expected to start Monday vs. the Chargers, per Jesse Minter. Acquired from Arizona; Tyler Huntley is on IR (toe). | Ravens.com, Yahoo, SI |
| Sam Darnold, QB | Seahawks | Out for Week 10 at Las Vegas (quad, ribs), per coach Mike Macdonald. | CBS Sports, Yahoo |
| Drew Lock, QB | Seahawks | Oblique. Tests came back good and Seattle plans to start him, but he has to get through practice. Jalen Milroe is next. | CBS Sports, Yahoo, Yardbarker |
| Deshaun Watson, QB | Browns | Reported as the starter vs. Houston; Todd Monken has not announced it. Shedeur Sanders started Week 9. Unresolved. | ESPN, Pro Football Rumors, Athlon |
| Patrick Mahomes, QB | Chiefs | Elbow. MRI showed no major injury; expected to play at Atlanta. | SI, Yahoo |
| J.J. McCarthy, QB | Giants | Hip. Limited on Monday's estimated report; John Harbaugh expects him to play Thursday. | Giants.com, SI, Yahoo |
| Kyler Murray, QB | Vikings | Grade 2 hamstring strain, week to week. Missed Monday night; Carson Wentz started. Unresolved for Green Bay. | NFL.com, SI, Yahoo |
| Gardner Minshew, QB | Cardinals | Right elbow, feared torn UCL; tests Monday and Tuesday. Rookie Carson Beck is in line to start. Unresolved. | NBC Sports, Arizona Sports, Yahoo |
| Justin Herbert, QB | Chargers | Left (non-throwing) middle finger. X-rays were negative and Jim Harbaugh said he should be good to go. | ESPN, Chargers.com |
| Puka Nacua, WR | Rams | Expected to go on IR with MCL and PCL sprains plus turf toe, per Sean McVay. | CBS Sports, KSL, Yahoo |
| Mike Evans, WR | 49ers | Achilles. Kyle Shanahan said he is not expecting him to be ready for Dallas. | 49ers Webzone, Rotowire, Yahoo |
| Deebo Samuel, WR | 49ers | Hamstring. Shanahan expects him back at practice Wednesday. Unresolved. | 49ers Webzone, Rotowire |
| Josh Jacobs, RB | Packers | Fractured finger. No timeline from Matt LaFleur. | The Athletic via ClutchPoints, Yahoo |
Statuses can change before kickoff. The Giants and Commanders filed estimated reports Monday for Thursday night, full reports for Sunday start Wednesday, November 11, and inactive lists come out 90 minutes before each game. The Eagles are on bye; Jalen Hurts is out for the season.
Other NFL Week 10 games
The Bills (7-1 after Monday night) are 7.5 to 8.5 at the Jets with a total of 50.5, up from 49.5. The Jaguars, who beat Baltimore 33-10 on Thursday, are 9.5 to 10.5 at Tennessee. Kansas City is 3.5 at Atlanta, and the Colts are 1.5 to 2.5 over Miami with the total down to 40.5.
New Orleans is now a 1.5-point favorite over Carolina in a game that decides who leads the NFC South, since both teams are 3-5. The 49ers are 3.5 to 4.5 in Dallas, and Kyle Shanahan does not expect Mike Evans to be ready. Monday night closes the week with the Chargers at the Ravens, total 37.5 to 38.5.
Where the standings sit after Week 9: the NFL playoff picture and our Week 10 power rankings. Every Week 9 result against the spread is in our NFL Week 9 recap.
Picking one team to win straight up this week? Our Week 10 survivor picks rank every favorite by win probability.
Prime-time game pages: Commanders vs Giants, Steelers vs Bengals and Chargers vs Ravens. Sunday game pages: Patriots vs Lions, Vikings vs Packers and Chiefs vs Falcons.