USC vs Indiana Prediction and Odds: Indiana -9.5, Hoover Off the Report
Indiana is a 9.5-point favorite over USC at five of seven books on SportsbookReview as of early Saturday, November 14, 2026, with bet365 and FanDuel at 8.5 and the total at 50.5. Using 9.5, that points to a final near Indiana 30, USC 20.5. Kickoff is Saturday at 3:30 PM ET on CBS from Memorial Stadium in Bloomington.
Josh Hoover is not on the Big Ten availability report, so he is available, but Indiana has not named a starter, per 247Sports. The Hoosiers will be without running back Turbo Richard, defensive lineman Kellan Wyatt and starting guard Joe Brunner, per ESPN.
USC vs Indiana odds at every book
| Book | Spread | Moneyline (USC / IND) | Total |
|---|---|---|---|
| BetMGM | IND -9.5 (-110) | +275 / -350 | 50.5 |
| bet365 | IND -8.5 (-114) | +275 / -350 | 50.5 |
| DraftKings | IND -9.5 (-112) | +275 / -345 | 50.5 |
| FanDuel | IND -8.5 (-113) | +265 / -330 | 50.5 |
| Fanatics | IND -9.5 (-110) | +275 / -350 | 50 |
| BetRivers | IND -9.5 (-112) | +275 / -375 | 50.5 |
| Caesars | IND -9.5 (-113) | +275 / -345 | 50.5 |
Five books have Indiana at -9.5, while bet365 (-114) and FanDuel (-113) still hang 8.5, so Indiana bettors should shop those two. Most books have USC at +275 on the moneyline, and Fanatics is the only book at 50 on the total.
The spread opened at Indiana -7 on SportsbookReview and has moved two and a half points toward the Hoosiers, even with 63% of spread tickets on USC. Lines move, so check the number before you bet.
USC vs Indiana prediction from the odds
That puts the market's prediction at Indiana 30, USC 20.5. Indiana's defense allows 12.4 points per game, fourth in FBS, and USC scores 32.4, per the AP's game preview.
| Source | Margin | Total |
|---|---|---|
| Market | Indiana by 8.5 to 9.5 | 50.5 |
| Prediction Tracker median | Indiana by 9.1 (std dev 2.8) | Not listed |
| Massey Ratings | Indiana 31, USC 21 | 52 |
The Prediction Tracker median (9.1) sits right on the line and Massey (10) is half a point above 9.5, so the market has caught up to both rating systems. Massey's 52-point total is the one number that leans a little away from the books.
How USC and Indiana got here
Indiana is 8-1 and beat Minnesota 23-16 on October 31, per the AP. The Hoosiers are 1-8 against the spread this season, a sign the market has priced them high all year.
USC is 7-2 and beat Ohio State 30-18 on October 31. Jayden Maiava has thrown for 2,525 yards with 20 touchdowns and 5 interceptions, per the AP, while the Trojans' run game ranks 108th in FBS at 129.4 yards per game.
USC vs Indiana injury report
| Player | Team | Status |
|---|---|---|
| Josh Hoover, QB | Indiana | Not on the availability report; starter not named |
| Turbo Richard, RB | Indiana | Out |
| Kellan Wyatt, DL | Indiana | Out |
| Joe Brunner, G | Indiana | Out |
| Rolijah Hardy, LB | Indiana | Questionable |
| A.J. Harris, CB | Indiana | Probable |
| Terrell Anderson and Corey Simms, WR | USC | Out |
| Kendarius Roddick and Trestin Castro, S | USC | Out |
| Taylor Johnson and Roman Marchetti, LB | USC | Out |
These are the Thursday night Big Ten availability designations, per 247Sports. Richard is Indiana's leading rusher with 745 yards, per Hoosier Huddle. The college report lists availability, not every injury, so Hoover may not be at full strength even if he starts. Recheck the game-day report before kickoff.
No lean on this game.
Our projection is Indiana by about 9.5, built from the market, the Prediction Tracker median of 9.1 and Massey's 10. That is the current number at most books, so there is no edge.
Hoover is off the report, but Indiana has not said who starts, and he was replaced at halftime of his last game. We do not post a lean while a starter is unsettled. Both teams last played on October 31.
We may also have a premium play on this game. A lean here is our editorial read of the market and can differ from the premium pick. Our free plays are on the free picks page, and our full card is on premium picks.
For the full Saturday board, see our college football Week 11 preview. Other games we broke down this week: Texas vs LSU, Missouri vs Georgia and Michigan vs Oregon.