NFL Week 5 Predictions 2026: Odds, Line Moves and Key Injuries
NFL Week 5 already has its first shock: the 0-4 Tampa Bay Buccaneers beat the Dallas Cowboys 24-16 on Thursday night as 9.5-point underdogs. The rest of the board has moved hard since Monday. The Philadelphia Eagles have gone from a 1.5-point lookahead favorite to 7.5-point underdogs in London, and the Baltimore Ravens have gone from -4 to +3.5 at Atlanta with Lamar Jackson's ankle unresolved. These NFL Week 5 predictions come from the market, as of Friday morning, October 9, 2026: odds for the 14 remaining games, the biggest line moves since open, the scores the lines imply and the injuries that could still move them.
Update: The NFL Week 6 preview is live, with every line, the biggest moves and the key injuries. Read it here.
NFL Week 5 odds for every game
Spreads and totals are the range across BetMGM, bet365, DraftKings, FanDuel, Fanatics, BetRivers and Caesars on SportsbookReview's board, cross-checked against the Las Vegas books on VegasInsider. Moneylines are DraftKings. The implied score splits the total by the spread, so it is the market's prediction, not ours. Times are Eastern.
| Game | Kickoff (ET) | Spread | Total | Moneyline (DK) | Implied score |
|---|---|---|---|---|---|
| Buccaneers at Cowboys | Thu 8:15 PM | Final: Buccaneers 24, Cowboys 16 | Closed 48.5 to 49.5 | Bucs won as a 9.5-point underdog | n/a |
| Eagles at Jaguars (London) | Sun 9:30 AM | JAX -7.5 | 41.5 | JAX -380 / PHI +300 | JAX 24.5, PHI 17 |
| Browns at Jets | Sun 1:00 PM | NYJ -2.5 | 39.5 to 40 | NYJ -135 / CLE +114 | NYJ 21, CLE 18.5 |
| Raiders at Patriots | Sun 1:00 PM | NE -3.5 | 45 to 45.5 | NE -198 / LV +164 | NE 24.5, LV 21 |
| Vikings at Saints | Sun 1:00 PM | MIN -2.5 | 41.5 to 42 | MIN -142 / NO +120 | MIN 22, NO 19.5 |
| Texans at Titans | Sun 1:00 PM | HOU -7.5 | 38 to 38.5 | HOU -425 / TEN +330 | HOU 23, TEN 15.5 |
| Giants at Commanders | Sun 1:00 PM | WAS -4.5 (Fanatics -3.5) | 41.5 to 42.5 | WAS -192 / NYG +160 | WAS 23, NYG 18.5 |
| Colts at Steelers | Sun 1:00 PM | PIT -2.5 | 43.5 to 44.5 | PIT -148 / IND +124 | PIT 23, IND 20.5 |
| Bears at Packers | Sun 1:00 PM | CHI -1.5 | 45.5 to 46.5 | CHI -120 / GB +100 | CHI 24, GB 22.5 |
| Bengals at Dolphins | Sun 1:00 PM | CIN -6.5 | 42.5 to 43.5 | CIN -325 / MIA +260 | CIN 24.5, MIA 18 |
| Broncos at Chargers | Sun 4:05 PM | DEN -3.5 | 41.5 to 42.5 | DEN -180 / LAC +150 | DEN 22.5, LAC 19 |
| Lions at Cardinals | Sun 4:25 PM | DET -5.5 (FanDuel -4.5) | 54 to 54.5 | DET -258 / ARI +210 | DET 30, ARI 24.5 |
| 49ers at Seahawks | Sun 4:25 PM | SEA -3.5 (bet365 -3) | 45.5 to 46.5 | SEA -162 / SF +136 | SEA 24.5, SF 21 |
| Ravens at Falcons | Sun 8:20 PM | ATL -3.5 (bet365 -3) | 43.5 to 44 | ATL -170 / BAL +142 | ATL 23.5, BAL 20 |
| Bills at Rams | Mon 8:15 PM | LAR -3.5 | 54 to 54.5 | LAR -175 / BUF +145 | LAR 29, BUF 25.5 |
Atlanta beat New Orleans 45-24 on Monday night, October 5, so the Falcons are 2-2 and the Saints 1-3. The lines in this table are from Friday morning, after most of the week's injury news. They can still move before kickoff, especially in games with an injured quarterback, so check the current number before you bet and shop the line across books.
Biggest NFL Week 5 line moves
Openers are from SportsbookReview's opener column unless noted. Lookahead lines posted before Week 4 can be far from where books reopened on Sunday night, so we flag that where it matters.
| Game | Opened | Now | Move |
|---|---|---|---|
| Eagles at Jaguars | PHI -1.5 (lookahead) | JAX -7.5 | 9 points to Jacksonville |
| Ravens at Falcons | BAL -4, total 47 | ATL -3.5, total 43.5 | 7.5 points to Atlanta; total down 3.5 |
| Giants at Commanders | WAS -3.5, total 44.5 | WAS -4.5, total 41.5 | 1 point to Washington; total down 3 |
| Browns at Jets | NYJ -1 | NYJ -2.5 | 1.5 points to the Jets |
| Bills at Rams | LAR -2.5 | LAR -3.5 | 1 point to the Rams |
| Vikings at Saints | MIN -1.5 | MIN -2.5 | 1 point to Minnesota |
| Texans at Titans | HOU -6.5 | HOU -7.5 | 1 point to Houston |
| Bengals at Dolphins | CIN -7.5 | CIN -6.5 | 1 point to Miami |
| Bears at Packers | total 44 | total 46 | Total up 2 |
Four NFL Week 5 games worth a closer look
Bills at Rams prediction: the two Super Bowl favorites
The Los Angeles Rams and Buffalo Bills are the top two teams on the Super Bowl board, and the Rams have moved from -2.5 to -3.5 at every major book this week, right onto the most important number in NFL betting. With the margin removed, DraftKings' moneylines make the Rams a 60.9% favorite, and the 54 to 54.5 total ties Lions at Cardinals for the highest on the board. Buffalo receiver DJ Moore aggravated a shoulder injury last week and did not practice Thursday. The full breakdown is in our Bills vs Rams prediction.
Ravens at Falcons prediction: waiting on Lamar Jackson
Lamar Jackson hurt his ankle against Tennessee on October 4, and the market has moved as if he will not play: Baltimore opened as a 4-point road favorite and Atlanta is now -3.5 at six of seven books, a 7.5-point swing, with the total down from 47 to 43.5. Jackson did not practice Wednesday and was not on the field for the open portion of Thursday's practice. Coach Jesse Minter said the team will not make rash decisions and that "when he's ready to play, he'll be ready to play." With the margin removed, DraftKings' moneylines make Atlanta a 60.4% favorite. Ravens linebacker Trey Hendrickson, cornerback Marlon Humphrey and center Cam Jurgens were also absent from Thursday's open practice. More in our Ravens vs Falcons prediction.
Eagles at Jaguars prediction: the biggest move of the week
No game has moved more. The lookahead line on SportsbookReview's board had the Philadelphia Eagles -1.5; Jacksonville was -4.5 by Monday and is now -7.5 at every major book, with DraftKings making the Jaguars a 76.0% favorite once the margin is removed. The Eagles' practice report explains most of it: running back Saquon Barkley and receivers DeVonta Smith and Hollywood Brown did not practice Wednesday or Thursday, per the team's official report. Jalen Hurts is not on the injury report.
49ers at Seahawks prediction: NFC West, unbeaten vs 3-1
The San Francisco 49ers are 4-0 after a 24-14 win over Denver, and they are still road underdogs. Seattle has moved from -3 to -3.5 at six of seven books (bet365 holds -3), and with the margin removed, DraftKings' moneylines make the Seahawks a 59.3% favorite.
Key NFL Week 5 injuries
These are the injuries most likely to move Week 5 lines, with practice participation from the Wednesday and Thursday reports, each confirmed by at least two sources. Final game designations (out, doubtful, questionable) come out Friday afternoon for Sunday games and Saturday for the Monday game, so check back before you bet.
| Player | Team | Injury | Practice this week |
|---|---|---|---|
| Lamar Jackson | BAL QB | Ankle | Did not practice Wednesday; not at the open part of Thursday practice. Unresolved. |
| Saquon Barkley | PHI RB | Hamstring | Did not practice Wednesday or Thursday. |
| DeVonta Smith | PHI WR | Hamstring | Did not practice Wednesday or Thursday. |
| Ja'Marr Chase | CIN WR | Concussion | Did not practice Wednesday; back at practice Thursday. |
| Tee Higgins | CIN WR | Groin, neck | Did not practice Wednesday; still sidelined Thursday. |
| Jayden Daniels | WAS QB | Elbow (Week 2) | Full participant; expected to return against the Giants. |
| Marcus Mariota | WAS QB | Knee (MCL sprain) | Did not practice Wednesday. |
| Patrick Surtain II | DEN CB | Ankle | Did not practice Wednesday. |
| DJ Moore | BUF WR | Shoulder | Did not practice Thursday. |
Statuses can change before kickoff. Teams issue final game designations on Friday for Sunday games, and inactive lists come out 90 minutes before kickoff. Quarterback news moves lines the most, so the Ravens at Falcons number is the one to watch into Sunday night.
The rest of the NFL Week 5 board
Buccaneers at Cowboys (Thursday): Tampa Bay won 24-16 for its first win of the season, as a 9.5 to 10.5-point underdog. The total closed at 48.5 to 49.5, so the under cashed as well.
Bengals at Dolphins: Cincinnati has come down from -7.5 to -6.5 against 0-4 Miami, with the total at 42.5 to 43.5. Ja'Marr Chase returning to practice on Thursday is the news to watch. Commanders vs Giants: Washington is -4.5 at six of seven books with Jayden Daniels a full participant in practice, and that total has fallen three points, from 44.5 to 41.5.
This preview is a market read with no pick attached. If you want our sides for Week 5, they come through free picks and premium picks.