College Football Week 10 Odds and Preview: Miami at Notre Dame, Oregon at Ohio State
College football Week 10 odds, as of Friday, November 6, 2026, 12:45 PM ET: Notre Dame is a 6.5 to 7.5-point favorite over unbeaten Miami on Saturday night, back up after a midweek dip to -5.5, Ohio State is -7.5 against Oregon after opening -14 with true freshman Luke Fahey expected at quarterback again, and Georgia is -3.5 at Ole Miss. Florida Atlantic beat UTSA 60-29 as a touchdown underdog on Thursday, and James Madison covered 54-23 at Southern Miss. Here is every major game, the line moves and the injuries that matter.
College football Week 10 odds for every major game
| Kickoff (ET) | Game | Spread | Total |
|---|---|---|---|
| Thu Final | UTSA @ Florida Atlantic | Final: Florida Atlantic 60, UTSA 29 (UTSA closed -7.5) | 89 points, Over 72.5 to 73.5 |
| Thu Final | James Madison @ Southern Miss | Final: James Madison 54, Southern Miss 23 (JMU closed -14.5) | 77 points, Over 57.5 to 58.5 |
| Fri 7:00 PM, ESPN | Virginia Tech @ SMU | SMU -5.5 to -6.5 | 56 to 56.5 |
| Fri 10:15 PM, ESPN | TCU @ Arizona | Arizona -6.5 to -7.5 | 46 to 46.5 |
| Sat 12:00 PM, ABC/ESPN | BYU @ Utah | Utah -3.5 to -4.5 | 48.5 |
| Sat 12:00 PM, ABC/ESPN | Texas @ Missouri | Texas -2.5 | 41.5 to 43 |
| Sat 12:00 PM | UCLA @ Minnesota | UCLA -4.5 to -5.5 | 37.5 to 39.5 |
| Sat 12:00 PM | Iowa @ Northwestern | Northwestern -2.5 (pick at one book) | 44.5 to 45.5 |
| Sat 12:45 PM | Arkansas @ Auburn | Auburn -10.5 to -11.5 | 53.5 to 54.5 |
| Sat 3:00 PM | Texas A&M @ South Carolina | South Carolina -6.5 to -7.5 | 51 to 52.5 |
| Sat 3:30 PM, CBS | Oregon @ Ohio State | Ohio State -7.5 | 45 to 46 |
| Sat 3:30 PM, ABC | Alabama @ LSU | LSU -5.5 to -6.5 | 52.5 |
| Sat 6:15 PM, ESPN | Kentucky @ Tennessee | Tennessee -6.5 | 49.5 to 50 |
| Sat 7:30 PM, NBC | Miami @ Notre Dame | Notre Dame -6.5 to -7.5 | 54.5 to 55.5 |
| Sat 7:30 PM, ABC | Georgia @ Ole Miss | Georgia -3.5 | 56.5 |
| Sat 7:30 PM | Michigan State @ Michigan | Michigan -13.5 to -14.5 | 39 to 39.5 |
| Sat 7:30 PM, CBS | Air Force @ Army | Army -3.5 | 44.5 |
| Sat 7:45 PM | Oklahoma @ Florida | Florida -5.5 to -6.5 | 45 to 45.5 |
Spreads and totals are the range across seven books on SportsbookReview's odds board Friday at 12:45 PM ET, cross-checked against VegasInsider's consensus board; every favorite matches. A range means books disagree. DraftKings has Miami at Notre Dame at 54.5 while Fanatics and BetRivers are at 55.5. Thursday and Friday kickoffs are November 5 and 6; Saturday is November 7. Our free plays for the week will be on the free picks page.
Biggest early line moves for Week 10
| Game | Opened | Now |
|---|---|---|
| Oregon @ Ohio State | Ohio State -14 | Ohio State -7.5 |
| Oklahoma @ Florida | Florida -4 | Florida -5.5 to -6.5 |
| Alabama @ LSU | LSU -4 | LSU -5.5 to -6.5 |
| TCU @ Arizona | Arizona -9 | Arizona -6.5 to -7.5 |
| Miami @ Notre Dame | Notre Dame -6.5 | Notre Dame -6.5 to -7.5 |
| Miami @ Notre Dame (total) | 54.5 | 54.5 to 55.5 |
| Georgia @ Ole Miss | Georgia -3 | Georgia -3.5 |
| James Madison @ Southern Miss | James Madison -15.5 | Closed -14.5; James Madison won 54-23 |
| Arkansas @ Auburn (total) | 48.5 | 53.5 to 54.5 |
Oregon at Ohio State is the move of the week: SportsbookReview's Sunday opener was Ohio State -14, and every book is at 7.5 as of Friday, with VegasInsider's consensus at 7. Ohio State's quarterback situation has not changed: Julian Sayin is still out indefinitely and Luke Fahey could start again, per SI earlier this week. Miami at Notre Dame opened at 6.5, dipped to 5.5 midweek and is 6.5 to 7.5 on Friday, with the total 54.5 to 55.5. LSU went from 4 to 5.5 against Alabama, Florida from 4 to 6.5 against Oklahoma, and South Carolina is now 7 to 7.5 over Texas A&M.
Miami vs Notre Dame odds and preview
Miami is 8-0 after surviving North Carolina 38-35 last week, a game it did not cover at -13.5. Notre Dame beat Navy 35-13 but did not cover -31.5. The early split at 3.5 did not hold: books are at 5.5 at most shops and 6.5 at DraftKings. The total climbed from 54.5 to 57.5.
Oregon vs Ohio State odds and preview
Ohio State lost 30-18 at USC with Luke Fahey making his first start in place of Julian Sayin, who is out indefinitely, and the Buckeyes did not score a touchdown until late. Oregon has been without quarterback Dante Moore since September. That is two backup-quarterback offenses in one game, which helps explain a total of only 46.5, and the spread has fallen from 14 to 7.5 since the open.
Georgia vs Ole Miss odds and preview
Georgia beat Florida 27-8 in Atlanta, forcing four turnovers and covering -11.5. Ole Miss beat Auburn 45-15 and covered -10.5. Every book is now at Georgia -3.5, just past the key number 3, and the total has posted at 56.5.
Alabama vs LSU odds and preview
LSU opened -4, sat at 5.5 midweek and is 6.5 at six of seven books on SportsbookReview as of Friday, with the total still 52.5. The move went through 6, which is as far as a line usually travels without an injury behind it.
Key injuries and player status for Week 10
| Player | Team | Pos | Status | Note |
|---|---|---|---|---|
| Julian Sayin | Ohio State | QB | Out indefinitely (throwing arm) | True freshman Luke Fahey started the 30-18 loss at USC |
| Dante Moore | Oregon | QB | Out for season (concussion) | Hurt Sept. 26 vs USC |
| Nico Iamaleava | UCLA | QB | Out for season (knee) | Ty Dieffenbach starting |
| Kamario Taylor | Mississippi State | QB | Out for season (toe) | Mississippi State hosts Vanderbilt |
| Aaron Philo | Florida | QB | Benched vs Georgia | Tramell Jones Jr. replaced him after Florida's third series; no starter named for Oklahoma |
| R.J. Mosley | Arizona | WR | Carted off Oct. 31 (left knee) | No diagnosis announced as of Nov. 1; Arizona hosts TCU Friday |
Florida's quarterback situation is the open question with the biggest effect on a Week 10 line: Aaron Philo started against Georgia after missing the Texas game with a right shoulder injury, then was benched for Tramell Jones Jr. Indiana has a bye, so Josh Hoover's shoulder will not show up on this board. We rechecked the Ohio State and Oregon quarterback notes on Friday, November 6; the other notes are as of November 1, and conference availability reports come out later in the week.
Other Week 10 college football games to watch
BYU at Utah at noon is the top Big 12 game, with Utah 8-0 and favored by 4.5 to 5.5. Texas is -2.5 to -3.5 at Missouri in the same window. Kentucky at Tennessee (Tennessee -6.5, 6:15 PM on ESPN) and Oklahoma at Florida (Florida -6.5) fill the SEC night slate behind Georgia and Ole Miss. Michigan is -12.5 to -13.5 against Michigan State, South Carolina is -7 to -7.5 against Texas A&M, and Air Force at Army is 7:30 PM on CBS with Army -3 to -3.5.